|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells.
|
31747859 |
2020 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This review will discuss these findings as well as their clinical significance and implications for the development of a strategy to target multiple molecules as a therapy for p53-R249S-harboring HCC.
|
30608603 |
2019 |
|
rs121912666
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In mutp53-Y220C-expressing hepatocellular carcinoma (HCC) cells, SLMP53-2-induced growth inhibition was mediated by cell cycle arrest, apoptosis, and endoplasmic reticulum stress response.
|
31405179 |
2019 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Droplet digital PCR detects high rate of TP53 R249S mutants in cell-free DNA of middle African patients with hepatocellular carcinoma.
|
29749584 |
2018 |
|
rs754332870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the KRAS gene showed only a G12C variation in one large cell carcinoma (LCC) patient, whereas variants were not found in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) cases.
|
30048458 |
2018 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We discovered that the TP53 R249S mutation occurred in 7.7% of the HCC patients, and it was significantly associated with poor diagnosis.
|
28412734 |
2017 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocellular carcinoma (HCC) that is highly related to hepatitis B infection and aflatoxin B1.
|
29225033 |
2017 |
|
rs28934578
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In addition, exogenous Δ40p53 expression significantly suppressed cell growth in HCC cells with wild-type TP53, and in those that were mutant or null for TP53 Notably, Δ40p53α-induced tumor suppressor activity was markedly attenuated in cells expressing the hot-spot mutant Δ40p53α-R175H, which lacks the transcription factor activity of p53.
|
27980070 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No publication bias was found for all the meta-analysis as suggested by the Begg funnel plot and Egger tests.These results suggested that variants MDM2 SNP309 and p53 Arg72Pro are susceptibility factors for HCC; however, more studies are warranted to validate the results.
|
28885338 |
2017 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No publication bias was found for all the meta-analysis as suggested by the Begg funnel plot and Egger tests.These results suggested that variants MDM2 SNP309 and p53 Arg72Pro are susceptibility factors for HCC; however, more studies are warranted to validate the results.
|
28885338 |
2017 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No publication bias was found for all the meta-analysis as suggested by the Begg funnel plot and Egger tests.These results suggested that variants MDM2 SNP309 and p53 Arg72Pro are susceptibility factors for HCC; however, more studies are warranted to validate the results.
|
28885338 |
2017 |
|
rs779196500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found that the L104P mutation in the VCX gene (Variable charge, X-linked) was absent in white blood cell samples, but present at 11.1% frequency in the adjacent tissues and increased to 14.6% in HCC tissues, suggesting that this mutation might be a tumor driver gene driving HCC carcinogenesis.
|
28412734 |
2017 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Furthermore, TP53 mutations were associated with shorter survival only in HBV-related HCC (p=0.02) whereas R249S mutations were identified exclusively in migrants.
|
25021421 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that Arg72Pro polymorphism in a WT p53 context may act as a primary driver of epigenetic changes in HCC.
|
25889455 |
2015 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that Arg72Pro polymorphism in a WT p53 context may act as a primary driver of epigenetic changes in HCC.
|
25889455 |
2015 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that Arg72Pro polymorphism in a WT p53 context may act as a primary driver of epigenetic changes in HCC.
|
25889455 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CG and GG genotypes in rs1042522 and heterozygote and homozygote in rs2279744 were significantly associated with an elevated risk of HCC.
|
25412941 |
2014 |
|
rs879253942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interrelationships among genetic C677T polymorphism of 5,10-methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic p53 oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma.
|
23996892 |
2014 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Thus, R249S may specifically cooperate with HBX in a pathway to HCC</span> that bypasses cirrhosis.
|
23200676 |
2013 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study shows moderate prevalence of aflatoxin B1-related p53 mutation (R249S) in HCC with or without HBsAg.
|
24460352 |
2013 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
R249S mutation was detected in 6.2% and 3.4% of the HCC and non-HCC groups, respectively, which was not significantly different.
|
23886144 |
2013 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We have analyzed the associations between 19 SNPs spanning the TP53 locus and a single specific aflatoxin-induced TP53 mutation (R249S) in 85 in hepatocellular carcinoma cases and 132 controls from Thailand.
|
23836507 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In subgroup analysis by ethnicity, the pooled results suggested that the p53 codon 72 Arg/Pro polymorphism was associated with an increased risk of HCC in Asians and Caucasians (for Asians, ORProPro vs. ArgArg + ArgPro=1.17 (95 % CI, 1.02-1.34), P OR=0.025; for Caucasians, ORProPro vs. ArgArg = 1.65 (95 % CI, 1.07-2.56), P OR=0.025; ORProPro vs. ArgArg + ArgPro=1.74 (95 % CI, 1.14-2.66), P OR=0.010).
|
23564481 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent.
|
23292895 |
2013 |